APOE4
Domain : Pathophysiology
Category : Pathophysiology
Simplified definition
A version of the gene encoding a protein called apolipoprotein E. It is a genetic risk factor for Alzheimer’s disease.
Source: Houria Aiouaz, for Alzheimer Foundation
Referenced definition
“[…] An isoform of the APOE gene in humans […].”
Source: Najm R, Jones EA, Huang Y. Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease. Molecular Neurodegeneration. 2019;14.
Context
“The APOE4 allele, present in approximately 10-15% of people, increases the risk for Alzheimer’s and lowers the age of onset. Having one copy of E4 (E3/E4) can increase your risk by 2 to 3 times while two copies (E4/E4) can increase the risk by 12 times.”
Source: Cognitive Vitality. What APOE means for your health. [Internet]. Nov 16, 2016 [cited on Sept 7, 2022].
Note
- “APOE4” stands for “Apolipoprotein E4”.
- A version of a gene is called an “allele”.
Spelling variation(s)
ApoE4GO FURTHER
