Familial form
Domain : Pathophysiology
Category : My daily life
Simplified definition
Refers to a disease that affects several people in the same family.
Source: Houria Aiouaz, for Alzheimer Foundation
Referenced definition
“A condition that tends to occur more often in family members than is expected by chance alone. A familial disease may be genetic (such as cystic fibrosis) or environmental (such as chicken pox).”
Source: Rxlist. Definition of familial. [Internet]. [cited on May 8, 2023].
Context
“The typical familial form of Alzheimer’s disease (FAD) accounts for about 1% [sic] of total Alzheimer’s disease (AD) cases.”
Source: Paracchini L, Beltrame L, Boeri L, Fusco F, Caffarra P et al. Exome sequencing in an Italian family with Alzheimer’s disease points to a role for seizure-related gene 6 (SEZ6) rare variant R615H. Alzheimer’s Research and Therapy. 2018;10.
Note
- Autosomal dominant familial forms of AD are extremely rare, accounting for less than 1% of cases.
- Autosomal dominant familial form” means that the disease can run in a family through every generation.