Cerebral glucose hypometabolism
Domain : Diagnosis
Category : Learn more
Simplified definition
A decrease in glucose (sugar) consumption by the cells that is visible during an imaging examination called PET Scan. In this case, neurons can no longer use glucose efficiently as a source of fuel.
Source: Houria Aiouaz, for Alzheimer Foundation
Referenced definition
“Cerebral glucose hypometabolism (CGHM) is characterized by diffuse or focal reduction in uptake of glucose by the brain as determined on a FDG PET-CT.”
Source: Kase AM, Bullock C, Parrondo R, Alhaj Moustafa M, Iqbal M, Li KD, Parent EE, Tun H. Neuropsychiatric Manifestations of Lymphoma-Associated Cerebral Glucose Hypometabolism Can Be Reversed by Intensive Glucose Supplementation. Blood and Lymphatic Cancer. 2022;12:17–21.
Context
“Hypometabolism caused by decreased glucose uptake is observed in specific areas of the AD-affected brain [the posterior cingulate, precuneus and temporo-parietal cortex]. Therefore, glucose hypometabolism […] in these regions is considered as a hallmark [sic] of AD.”
Source: Szablewski L. Brain Glucose Transporters: Role in Pathogenesis and Potential Targets for the Treatment of Alzheimer’s Disease. International Journal of Molecular Sciences. 2021 Jul 29;22(15):8142.